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Stay Young & Healthy - Diabetes Developed in Fish

Indian scientists have succeeded in inducing the most prevalent type II diabetes in a freshwater fish, which could turn out to be a convenient animal model to treat the disease.

The disease, which accounts for 95 per cent cases of the disorder, was induced by feeding the Indian perch (Anabas testudineus) with a compound called palmitate. This compound belongs to a class called free fatty acid, which mainly causes for development of diabetes.

Scientists also found development of insulin resistance, an indicator of type II diabetes. Insulin resistance is a condition in which insulin, a chemical produced by the pancreas, is not able to act on glucose leading to accumulation of glucose in the blood.

Type II diabetes is an epidemic disease seriously threatening global human health. The disease signifies normal or more levels of insulin, but its action is inhibited which restricts glucose uptake, causing high levels of sugar in the blood.

More that 95 per cent diabetic patients are type II diabetic and the prevalence of this disease has increased recently.

Thus, the disease requires serious attention with pressing need for animal models to pursue development of new therapeutic agents, the scientists said.

Elevated level of free fatty acids is associated with impaired insulin function and is commonly linked with obesity and type II diabetes.

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