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Young & Healthy - Diabetes Developed in Fish |
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Indian scientists
have succeeded in inducing the most prevalent
type II diabetes in a freshwater fish,
which could turn out to be a convenient animal
model to treat the disease.
The disease, which accounts for 95 per cent
cases of the disorder, was induced by feeding
the Indian perch (Anabas testudineus) with a
compound called palmitate.
This compound belongs to a class called free
fatty acid, which mainly causes for development
of diabetes.
Scientists also found development of insulin
resistance, an indicator of type II diabetes.
Insulin resistance is a condition in which insulin,
a chemical produced by the pancreas, is not
able to act on glucose leading to accumulation
of glucose in the blood.
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Type
II diabetes is an epidemic disease seriously threatening
global human health. The disease signifies normal
or more levels of insulin, but its action is inhibited
which restricts glucose uptake, causing high levels
of sugar in the blood.
More that 95 per cent diabetic patients are type
II diabetic and the prevalence of this disease
has increased recently.
Thus, the disease requires serious attention with
pressing need for animal models to pursue development
of new therapeutic agents, the scientists said.
Elevated level of free fatty acids is associated
with impaired insulin function and is commonly
linked with obesity and type II diabetes. |
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